Preparation and dissolution property of ipriflavone solid dispersion

AIM: To prepare and identify ipriflavone (IP) solid dispersion, and determi ne its dissolution property. METHODS: The solvent method was used for prepa ration and differential scanning calorimetry (DSC), X-ray diffraction and i nfrared spectrophotometry for identification of IP solid dispersion. The di ssolution of the dispersion was determined with paddle method. RESULTS: The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1 :8) in artificial gastric juice is 6.15 times as high as that of IP alo ne. The DSC curves, X-ray diffraction patterns and infrared spectrophotomet ries of IP have been changed obviously by the dispersion. CONCLUSION: The d issolution of IP is increased by solid dispersion method.