Inflammatory myofibroblastic tumor of the skin

We report a case of inflammatory myofibroblastic tumor (IMF) of the skin in a female with a history of Wegeners granulomatosis. The patient had a pain less, erythematous, and indurated lesion of the left elbow. The resected sp ecimen revealed a 4 cm x 3 cm nodule involving the entire dermis and superf icial portions of subcutis with a stellate profile at scanning magnificatio n. There were spindle cells in fascicles and whorls and a mixed inflammator y cell infiltrate of plasma cells, lymphocytes, neutrophils, and eosinophil s. The spindle cells were immunoreactive for vimentin, muscle specific acti n, and smooth muscle actin. The polyclonal and polymorphous nature of the i nflammatory cells was confirmed by immunohistochemical studies. This is the first case of IMF of the skin documented by immunostaining.