Sebaceous carcinoma of the vulva

Extraocular sebaceous carcinoma is an uncommon neoplasm usually localized o n the head and neck. Sebaceous glands are abundant on the vulva, but Vulvar sebaceous carcinoma is an uncommon neoplasm. To our knowledge, there are o nly five previously reported cases of sebaceous carcinoma on this location. We report an additional case of vulvar sebaceous carcinoma associated with Bowen's disease in the overlying epidermis. The patient also had bowenoid papulosis involving the skin of labia majora. We analyzed by immunohistoche mistry, Southern blot hybridization, and polymerase chain reaction (PCR) te chniques for the presence of DNA of human papilloma viruses (HPVs) in the s pecimen of sebaceous carcinoma and in lesions of bowenoid papulosis. Immuno histochemistry, Southern blot hybridization, and PCR studies in specimens o f bowenoid papulosis lesions and sebaceous carcinoma did not detect DNA of HPVs. A significant increase in intranuclear p53 staining was demonstrated in several areas of neoplastic aggregations of sebaceous carcinoma.