Risk of breast cancer according to use of antidepressants, phenothiazines,and antihistamines

In laboratory studies, some antidepressants caused increased growth of mamm ary tumors. The relation of use of these drugs to the development of breast cancer was examined in a hospital-based case-control study. Information, i ncluding lifetime medication history, was collected by interview from 5,814 women with primary breast cancer diagnosed within the previous year, 5,095 women with primary malignancies of other sites, and 5,814 women with other conditions. Relative risks were estimated by using unconditional multiple logistic regression for regular use (greater than or equal to 4 days per we ek for 24 weeks beginning greater than or equal to 1 year before admission) of antidepressants and structurally similar drugs. With reference to never use of each drug, relative risks were statistically compatible with 1.0 fo r selective serotonin reuptake inhibitors (SSRI), tricyclics, other antidep ressants, phenothiazines, and antihistamines; results were very similar usi ng both control groups. There were no significant increases in risk for any category of regular use, stratified according to cumulative duration of us e or time interval since the most recent use or for any individual drug wit hin the broader classes. However, the estimate for regular SSRI use in the previous year, 1.8, was of borderline statistical significance (95% confide nce interval: 1.0, 3.3). The findings do not support an overall association between the use of antidepressants, phenothiazines, or antihistamines and breast cancer. However, the results for SSRIs are not entirely reassuring.