Resistant epidermolysis bullous acquisita with severe ocular involvement: successful extracorporeal photochemotherapy

Background. Epidermolysis bullosa aquisista can leave several functional se quelae. The lesions sometimes resist treatment, Case report. We report a case of a 25-year-old young man presenting with a severe epidermolysis bullosa acquisita confirmed by the electronic immunomi croscopy. He had a major ocular involvement with symblepharon and cicatrici al synechial lesions, He was almost blind because of corneal scars. Ail imm unosuppressive treatments had failed: systemic corticoids, cyclosporin, aza thioprine. The introduction of extracorporeal photochemotherapy resulted in the healing of the lesions, after a total of 32 procedures. All treatment are now stopped, and the lesions are purely cicatricial, without any relaps e of the disease since 9 months. Corneal grafts are now under process, to t ry to recover a part of the lost visual acuity. Discussion, This case demonstrates the efficacy of extracorporeal chemother apy to be tried in case other treatments faile.