Simultaneous assessment of function and perfusion during dipyridamole-handgrip Tc-99m sestamibi imaging in chronic coronary artery disease

The main goal of this work was to know the value of ventricular function in addiction to perfusion Tc-99m sestamibi images in the assessment of corona ry artery disease (CAD) when using dipyridamole (DIP) associated to isometr ic exercise. We analyzed 52 patients with suspected CAD; 40 of them had cor onary lesions greater than or equal to 50% and 12 patients without CAD, con forming study and control groups, respectively. Twenty-eight patients had p rior myocardial infarction. A two-day sestamibi protocol was employed with i.v. DIP-handgrip and rest injections, acquiring EGG-gated first pass and p lanar perfusion images. Sensitivity for perfusion images was 85% and specificity was 91.7%. There w as no change between rest and DIP ejection fraction (EF) in controls. CAD p atients presented a significant EF decrease with DIP (p: 0.0015). Patients with ischemia in perfusion images had larger EF decrease (p: 0.0001). For t he analysis, an EF drop greater than or equal to 5% and any wall motion abn ormality (WMA) were considered as having an abnormal response to DIP. CAD s ensitivity improved significantly to 92.5% when adding EF drop and to 90% w hen adding WMA parameters, but specificity decreased to 75% with EF drop, a nd to 58.3% with WMA. In conclusion, first pass parameters from DIP-isometr ic exercise in addition to perfusion images are not a significant help in t he assessment of CAD.