Ifosfamide in non-small-cell lung cancer

Ifosfamide has been used in combination with several drugs including cispla tin, giving rise to multiple doublets and triplets including the ifosfamide -cisplatin-mitomycin regimen (Cullen's MIC regimen) that has been commonly used in Europe. However, new combinations are challenging the activity of t he old chemotherapy regimens, especially in terms of objective response rat e and time to progressive disease, as has been shown in several phase III r andomized trials. Among these new combinations, ifosfamide-vinorelbine and ifosfamide-gemcitabine-cisplatin are especially promising. In this paper, s everal ifosfamide doublets and triplets are reviewed.