Does intraduodenal administration of sucrose polyester (olestra) cause satiation in humans?

The effect of intraduodenally perfused sucrose polyester, digestible fat or saline was compared on hunger feelings, food intake and the putative satie ty hormones cholecystokinin and pancreatic polypeptide in plasma of 18 heal thy volunteers in a double-blind three-period cross-over study. Sucrose pol yester, digestible fat or saline was perfused directly into the duodenum. D uring the perfusion period a standardized meal was provided and the volunte ers were asked to eat until satiation. Relative to saline perfusion, digest ible fat, but not sucrose polyester, decreased prospective feeding intentio ns, increased a feeling of fullness and reduced hunger feelings in women (N =9) but not in men (N=9). Sucrose polyester tended to suppress appetite rat ings less effectively than digestible fat in women. Food intake did not var y among fat, sucrose polyester and saline. Cholecystokinin and pancreatic p olypeptide concentrations increased over basal value and in men as in women during perfusion of digestible fat, but not during perfusion of sucrose po lyester or saline. It is concluded that at the level of the duodenum sucros e polyester suppresses hunger less effectively than digestible fat, and it does not release cholecystokinin and pancreatic polypeptide into plasma. (C ) 1999 Academic Press.