Orbital metastasis due to interval lobular carcinoma of the breast - A potential mimic of lymphoma

A 53-year-old woman had an orbital mass composed of a neoplastic small roun d cell infiltrate and no apparent extraorbital primary tumor. Although the initial diagnosis was primary orbital lymphoma, a combination of mucin hist ochemistry and immunohistochemical staining for cytokeratin and estrogen re ceptors led to the discovery of an impalpable lobular carcinoma of the brea st. We discuss how detailed histopathological assessment can lead to benefi cial therapy.