Striatal perfusion of indomethacin attenuates dopamine increase in immature rat brain exposed to anoxia: an in vivo microdialysis study

Using in vivo microdialysis and HPLC, we examined the effects of indomethac in on extracellular dopamine (DA) in the striatum of immature rats submitte d to anoxia. Rat pups in two indomethacin groups received intrastriatal per fusion of either 1 mM or 5 mM indomethacin throughout the experiment. The D A level reached 1185 +/- 400% of the basal level during anoxia; in contrast , the peak levels of DA were only 307 +/- 63%, 153 +/- 35% in indomethacin groups (p < 0.05). We consider that this suppression would be one of the me chanisms of the protective effect of indomethacin on hypoxic ischemic encep halopathy. (C) 1999 Elsevier Science B.V. All rights reserved.