Time-course of the change in blood pressure level in magnesium-deficient Wistar rats

The aim of the present study was to determine whether a severely Mg-deficie nt diet can modify blood pressure in rats and whether these alterations in blood pressure are associated with a change in in vivo cardiovascular react ivity, alteration in plasma lipids and modification of the production of ho rmones involved in blood pressure regulation. Weanling male Wistar rats wer e pair-fed for 40 weeks with control (960 mg Mg/kg) and Mg-deficient (80 mg Mg/kg) diets. At 2 weeks, blood pressure was lower in Mg-deficient rats, w hile heart rate was greater than in controls. Mg-deficiency-induced hypoten sion was transitory and the administration of antihistamine agents inhibite d the appearance of this hypotensive phase, suggesting that histamine may p lay a role in lowering blood pressure. Until 15 weeks, blood pressures were similar for control and Mg-deficient rats. Thereafter, blood pressure rose gradually until the end of the experiment in Mg-deficient rats. Heart rate remained higher in hypertensive Mg-deficient rats. After 21 weeks, in vivo cardiovascular reactivity to noradrenaline was lower and reactivity to ang iotensin II was unchanged in hypertensive Mg-deficient rats. At 2 and 21 we eks, hypomagnesaemia was accompanied by higher plasma levels of Ca, triacyl glycerols and cholesterol. Plasma renin activity was higher at week 2, wher eas levels of plasma angiotensin converting enzyme were lower at 2 and 21 w eeks in Mg-deficient rats. The plasma aldosterone level was higher at 2 and 21 weeks while the vasopressin level did not change. Plasma corticosterone levels were lower at 2 weeks and higher at 21 weeks. It is concluded that Mg deficiency induced a transitory hypotension followed by a sustained hype rtension in rats. The release of vasodilator inflammatory agents may contri bute to the early hypotension. The hypertensive phase may be explained by t he increased sympathetic nervous activity induced by Mg deficiency even tho ugh the contribution of several hormonal systems implicated in blood pressu re regulation remains to be elucidated.