Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus

Citation
G. Ikeda et al., Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus, CANCER, 86(8), 1999, pp. 1396-1405
Citations number
46
Categorie Soggetti
Oncology,"Onconogenesis & Cancer Research
Journal title
CANCER
ISSN journal
0008543X → ACNP
Volume
86
Issue
8
Year of publication
1999
Pages
1396 - 1405
Database
ISI
SICI code
0008-543X(19991015)86:8<1396:PSOBFI>2.0.ZU;2-Y
Abstract
BACKGROUND. Esophageal carcinoma is one of the most lethal tumors. Therefor e, it is important to identify prognostic factors for patients with this di sease. The objective of this study was to clarify the relation between clin icopathologic and biologic factors in esophageal carcinoma and to determine the prognostic significance of different biologic factors. METHODS, DNA ploidy pattern, Ki-67 labeling index (LI), and cyclin D1 and p 53 protein expression were examined and detailed pathologic examinations we re conducted on tumors from 53 patients (46 males and 7 females with a mean age of 66 years [range, 47-85 years]) with surgically resected esophageal squamous cell carcinoma and the prognostic value of these factors was evalu ated. RESULTS, Of the 53 esophagus carcinomas examined, 26 (49%) were classified as DNA diploid. The mean Ki-67 LI was 45 +/- 4.9% (range, 10.5-86.1%). p53 expression was detected in 38 of the carcinomas (71.7%) and cyclin D1 expre ssion was detected in 35 (66%). Various prognostic factors were examined us ing the Cox stepwise regression model, four of which were found to correlat e with overall survival: tumor size (P = 0.0346), lymph node status (P = 0. 0384), Ki-67 LI (P = 0.0161), and p53 expression (P = 0.001). Lower Ki-67 L I and a lower rate of p53 expression were detected in the long term surviva l group (> 3 years) compared with the short term survival group (P = 0.0004 5 and P = 0.0023, respectively). CONCLUSIONS. The biologic factors of Ki-67 LI and p53 expression, as well a s clinicopathologic factors, may be used as independent prognostic factors for patients with esophageal carcinoma. However. the results of the current study do not support cyclin D1 expression as a prognostic factor. (C) 1999 American Cancer Society.