Studies on the reaction between ketorolac, feprazone and serum albumin

In paper, by applying fluorescence quenching method and energy transfer tec hnique, the interaction of serum albumin(BSA and HSA) with ketorolac and fe prazone was investigated. The binding sites and binding constants were obta ined. According to the thermodynamic parameters, the main sorts of binding force can be known. The results show that two drugs and protein have strong interactions. The mechanism of quenching belongs to static quenching and t he main sort of binding force is static-electricity gravitation.