Preparation and properties of magnesium(II) compounds with some bioactive ligands

Synthesis, analytical data, IR spectra, as well as antimicrobial activities of seventeen Mg(II) compounds are presented. By means of IR spectral analy sis the stereochemistry around Mg(II) atom in the compounds had been studie d. Pyridine, nicotinamide, and N,N-diethylnicotinamide were coordinated to Mg(II) through the nitrogen atom of their heterocyclic ring. IR data sugges t a unidentate coordination of carboxylate ions to Mg(II). The antimicrobia l effects have been tested on various strains of bacteria, yeasts, and fila mentous fungi. The found antimicrobial effect of the compounds is decreased in the sequence: dermatophytes, phytopathogenic fungi, yeasts, and bacteri a. Significant morphological changes of Botrytis cinerea were observed by t he compounds VI and XVI. The highest antimicrobial effects were manifested by the compound V, especially against dermatophytic fungi Trichophyton terr estre and Microsporum gypseum (IC50 = 623 mu g cm(-3) and 642 mu g cm(-3), respectively).