Separation of chiral basic drugs with sulfobutyl-beta-cyclodextrin in capillary electrophoresis

Authors
Ren, XQ Dong, YY Liu, JY Huang, AJ Liu, HW Sun, YL Sun, ZP
Citation
Xq. Ren et al., Separation of chiral basic drugs with sulfobutyl-beta-cyclodextrin in capillary electrophoresis, CHROMATOGR, 50(5-6), 1999, pp. 363-368
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Spectroscopy /Instrumentation/Analytical Sciences
Journal title
CHROMATOGRAPHIA
ISSN journal
00095893 → ACNP
Volume
50
Issue
5-6
Year of publication
1999
Pages
363 - 368
Database
ISI
SICI code
0009-5893(199909)50:5-6<363:SOCBDW>2.0.ZU;2-0
Abstract
Separation of the enantiomers of 22 chiral basic drugs not previously separ ated with sulfobutyl-beta-cyclodextrin (SBE-beta-CD) as a chiral selector h as been investigated by capillary zone electrophoresis. By dissolving the d rug in Britton-Robinson buffer then optimization of selector concentration, pH, and amount injected, the enantiomers of 19 drugs were successfully sep arated, two for the first time.