Y. Taniguchi et al., Myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy, CLIN NEPHR, 52(4), 1999, pp. 253-255
In September 1997, a 68-year-old woman was found to have proteinuria and re
nal dysfunction. In December 1997, renal biopsy revealed necrotizing cresce
ntic glomerulonephritis and membranous glomerulonephropathy. We diagnosed m
yeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing cre
scentic glomerulonephritis and membranous glomerulonephropathy because of t
he presence of necrotizing cellular crescents and spike lesions in the sube
pithelial region of the glomerular basement membrane. After steroid therapy
, the antibody level and the incidence of cellular crescents showed a decre
ase. This is a rare case of myeloperoxidase antineutrophil cytoplasmic anti
body-positive necrotizing crescentic glomerulonephritis associated with mem
branous glomerulonephropathy.