Myeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis and membranous glomerulonephropathy

In September 1997, a 68-year-old woman was found to have proteinuria and re nal dysfunction. In December 1997, renal biopsy revealed necrotizing cresce ntic glomerulonephritis and membranous glomerulonephropathy. We diagnosed m yeloperoxidase antineutrophil cytoplasmic antibody-positive necrotizing cre scentic glomerulonephritis and membranous glomerulonephropathy because of t he presence of necrotizing cellular crescents and spike lesions in the sube pithelial region of the glomerular basement membrane. After steroid therapy , the antibody level and the incidence of cellular crescents showed a decre ase. This is a rare case of myeloperoxidase antineutrophil cytoplasmic anti body-positive necrotizing crescentic glomerulonephritis associated with mem branous glomerulonephropathy.