NEUROPEPTIDE-Y RECEPTOR GENES ON HUMAN-CHROMOSOME-4Q31-Q32 MAP TO CONSERVED LINKAGE GROUPS ON MOUSE CHROMOSOME-3 AND CHROMOSOME-8

Npy1r and Npy2r, the genes encoding mouse type 1 and type 2 neuropepti de Y receptors, have been mapped by interspecific backcross analysis. previous studies have localized the human genes encoding these recepto rs to chromosome 4q31-q32. We have now assigned Npy1r and Npy2r to con served linkage groups on mouse Chr 8 and Chr 3, respectively, which co rrespond to the distal region of human chromosome 4q. Using yeast arti ficial chromosomes, we have estimated the distance between the human g enes to be approximately 6 cM. Although ancient tandem duplication eve nts may account for some closely spaced G-protein-coupled receptor gen es, the large genetic distance between the human type 1 and type 2 neu ropeptide Y receptor genes raises questions about whether this mechani sm accounts for their proximity. (C) 1997 Academic Press.