In order to know the prevalence and risk factors for coinfections by human
immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus
(HCV) among injecting drug users (IDUs), a cross-sectional study was carri
ed out in two prisons of the province of Cantabria, northern Spain. Three h
undred and sixty-two IDU inmates were recruited. All inmates were interview
ed and their blood tested for HIV, HBV and HCV. Crude and multiple risk fac
tor adjusted for (by polychotomous logistic regression) odds ratios were ca
lculated. Prevalence of HBV-HCV coinfection (42.5%) was higher than HIV-HBV
-HCV coinfection (37.3%), whereas monoinfections were very uncommon (overal
l: 13%). Long-term injectors and reincarceration were the foremost risk fac
tors for both coinfections, showing a trend between the degree of associati
on and the number of viruses infecting a patient. No significant relationsh
ip between coinfection status and sexual practices was observed. The result
s related to coinfections are consistent with previous studies of prevalenc
e and risk factors for HIV, HBV and HCV, in indicating that the high rates
of coinfections among IDU inmates emphasise the need to harm-reduction poli
cy across prisons in Spain.