Synthesis and antimicrobial activity of Schiff and Mannich bases of isatinand its derivatives with pyrimidine

Isatin and its derivatives have been reacted with 4-(4'-chlorophenyl)-6-(4" -methyl phenyl)-2-aminopyrimidine to form Schiff bases and the N-Mannich ba ses of these compounds were synthesized by reacting them with formaldehyde and several secondary amines. Investigation of antimicrobial activity of th e compounds was made by the agar dilution method against 28 pathogenic bact eria, eight pathogenic fungi and anti-HIV activity against replication of H IV-I (III B) in MT-4 cells. The compounds are significantly active against bacteria and fungi. (C) 1999 Elsevier Science S.A. All rights reserved.