The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX)

Authors
Giverhaug, T Loennechen, T Aarbakke, J
Citation
T. Giverhaug et al., The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX), GEN PHARM, 33(4), 1999, pp. 341-346
Citations number
22
Categorie Soggetti
Pharmacology & Toxicology
Journal title
GENERAL PHARMACOLOGY
ISSN journal
03063623 → ACNP
Volume
33
Issue
4
Year of publication
1999
Pages
341 - 346
Database
ISI
SICI code
0306-3623(199910)33:4<341:TIO6(A>2.0.ZU;2-M
Abstract
The antimetabolites 6-mercaptopurine (6-MP) and metliotrexate (MTX) are the cornerstones in the maintenance treatment of children's acute lymphoblasti c leukemia (ALL). The biochemical mechanisms underlying the increased thera peutic efficacy of the combination of these drugs have not yet been elucida ted. However, both drugs interact with important pathways, such as purine d e novo synthesis (PDNS), purine salvage, and methylation reactions. A revie w of the mechanistic aspects of the interactions between 6-MP and MTX is gi ven. (C) 1999 Elsevier Science Inc. All rights reserved.