Gompertzian growth as a self-similar and allometric process

Authors
Citation
Z. Bajzer, Gompertzian growth as a self-similar and allometric process, GROW DEV AG, 63(1-2), 1999, pp. 3-11
Citations number
56
Categorie Soggetti
Medical Research General Topics
Journal title
GROWTH DEVELOPMENT AND AGING
ISSN journal
10411232 → ACNP
Volume
63
Issue
1-2
Year of publication
1999
Pages
3 - 11
Database
ISI
SICI code
1041-1232(199921)63:1-2<3:GGAASA>2.0.ZU;2-8
Abstract
The Gompertz law of growth has puzzled scientists for decades: while it suc cessfully described growth kinetics of various biological systems (e.g., tu mor growth), its foundation has remained unclear. In this paper I recognize the Gompertzian growth as founded on self-similarity, which is so abundant in natural phenomena that it justifiably represents a fundamental natural paradigm. The self-similarity leads to an allometric principle: the sizes o f a given biological system at different times are related by a simple powe r law. The stated relation can be also viewed as basic functional growth eq uation with unique nonconstant solutions being the Gompertz and the exponen tial functions. This equation also provides the description of growth and r egression dynamics in terms of a difference equation which already has foun d practical application in characterizing tumor growth kinetics.