A novel type of a second epoxy bridge in eunicellane diterpenes: Isolationand characterization of massileunicellins A-C from the gorgonian Eunicellacavolinii

Authors
Mancini, I Guella, G Zibrowius, H Laurent, D Pietra, F
Citation
I. Mancini et al., A novel type of a second epoxy bridge in eunicellane diterpenes: Isolationand characterization of massileunicellins A-C from the gorgonian Eunicellacavolinii, HELV CHIM A, 82(10), 1999, pp. 1681-1689
Citations number
37
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
82
Issue
10
Year of publication
1999
Pages
1681 - 1689
Database
ISI
SICI code
0018-019X(1999)82:10<1681:ANTOAS>2.0.ZU;2-M
Abstract
Massileunicellins A (7), B (9), and C (11) - which show a novel type of a s econd epoxy bridge in eunicellane diterpenes - were isolated from the gorgo nian Eunicella cavoliniii collected near Marseille. Structural assignments are based on NMR and MS data of these compounds and of their ketal derivati ves 8, 10, and 12. Negligible activity of the massileunicellins on L1210 an d KB tumor cell lines, and similar results for related known compounds, cas t doubt on high cytotoxicity reported for the latter by other authors.