DNA BASES ATTACK BY REACTIVE METABOLITES PRODUCED DURING CARBON-TETRACHLORIDE BIOTRANSFORMATION AND PROMOTION OF LIVER MICROSOMAL LIPID-PEROXIDATION

Authors
CASTRO GD GOMEZ MID CASTRO JA
Citation
Gd. Castro et al., DNA BASES ATTACK BY REACTIVE METABOLITES PRODUCED DURING CARBON-TETRACHLORIDE BIOTRANSFORMATION AND PROMOTION OF LIVER MICROSOMAL LIPID-PEROXIDATION, Research communications in molecular pathology and pharmacology, 95(3), 1997, pp. 253-258
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Pathology,Biology
Journal title
Research communications in molecular pathology and pharmacology → ACNP
ISSN journal
10780297
Volume
95
Issue
3
Year of publication
1997
Pages
253 - 258
Database
ISI
SICI code
1078-0297(1997)95:3<253:DBABRM>2.0.ZU;2-Z
Abstract
Free radicals produced during carbon tetrachloride biotransformation a nd the promoted lipid peroxidation process of liver microsomal lipids are able to attack the DNA bases guanine, cytosine and thymine to give at least three altered bases. They were identified as 2,6-diamino-4-h ydroxy-5-formamidopyrimidine (FapyGua); 5-hydroxycytosine (5OHCyt) and 5-hydroxymethyluracil (5OHMeU). No adenine adducts were detected. If these altered bases were formed during carbon tetrachloride poisoning and were not adequately repaired before cell replication, serious perm anent consequences for liver cell DNA could be expected and this might be somehow involved in the liver carcinogenic effects of the haloalka ne.