Sc. Sharma et al., Structure elucidation of two mow metabolites of 7,8,9,10-tetrahydroazepino-[2, 1-b]quinazolin-12(6H)-one, a potent bronchodilator: Part II, I J CHEM B, 38(7), 1999, pp. 814-817
Citations number
5
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY
In vivo metabolic studies of 7,8,9,10-tetrahydroazepino [2,1-b]quinazolin-1
2(6H)-one, a potent bronchodilator have been carried, out in rhesus monkeys
and rats, in order to see whether this activity is due to the parent compo
und or due to its metabolites formed. Structure of these metabolites have b
een established by UV, IR, H-1-NMR, C-13-NMR and mass spectral data. The st
ructure assigned to these metabolites have been further confirmed by their
partial synthesis (Scheme I and II). Finally the bronchodilatory activity o
f these metabolites has been studied in comparison to its parent compound a
nd it is observed that none of the metabolites show any bronchodilatory act
ivity.