An efficient and convenient procedure for the preparation of 3-cinnamoyl-2-
methyl-1,8-naphthyridines 2 has been achieved by the Claisen-Schmidt conden
sation of 3-acetyl-2-methyl-1,8-naphthyridine 1 with aromatic aldehydes in
the presence of KOH in the solid state. The reaction proceeds efficiently a
t room temperature in good yields and in a state of high purity.