Synthesis and antimicrobial activity of 6-bromo-1-butyl-3-ethoxycarbonyl-2-(4-chloro-phenoxy) methyl-5-(4-phenyl-5-mercapto-1,2,4-triazol-3-yl) methoxyindole

6-Bromo-1-butyl-3-ethoxycarbonyl-5-ethoxycarbonylmethoxy-2-methylindole (2) was brominated regioselectively with NBS in presence of benzoylperoxide in CCl4 to secure 2-bromomethylindole derivative (3), which was then reacted with 4-chlorophenol to get corresponding 2-(4-chlorophenoxy) methylindole d erivative (4). Hydroysis of compound (4) by ethanolic NaOH gave the diacid (5). Indole diester (4) was reacted with hydrazine hydrate to give exclusiv ely 3-ethoxycarbonylindoie-5-yloxyacetic acid hydrazide (6) which was treat ed with phenylisothiocyanate followed by NaOH (4%) solution to obtain the d esired 6-bromo-1-butyl-2-(4-chlorophenoxy) methyl-3-ethoxy carbonyl-5-(4-ph enyl-5-mercapto-1,2,4-triazol-3-yl) methoxyindole (9). All the newly synthe sized compounds were screened for their antimicrobial activities.