In vitro and in vivo evaluation of a new polysulfone membrane for hemodialysis. Reference methodology and clinical results (Part. 2: In vivo study)

Different high flux membranes have been recently developed. The present stu dy is aimed at describing the technical features and the clinical performan ces of a new high flux polysulfone membrane (T-sulfone, Toray, Japan). The study has been carried out on two different dialyzers (surface area = 1.3 a nd 1.8 m(2)). The filters have been tested in vivo during hemodialysis and hemodiafiltration. The in vivo study was carried out on 12 ESRD patients on regular hemodialys is treatment The protocol was reviewed and approved by the local ethical co mmittee. The in vivo clearances (K) at 300 ml/min of blood flow are reported in the following Table: [GRAPHICS] Beta-2-m reduction ratio exceeded 50% in all sessions. Beta-Pm mass balance executed by collection of spent dialysate and elution from the used filter s evidenced that removal is obtained mostly by filtration while absorption is negligible. Excellent tolerance and hemocompatibility was observed in al l the studied sessions.