Chiral separations using polymeric dipeptide surfactants: effect of numberof chiral centers and steric factors

Two polymeric dipeptide chiral surfactants (PDCSs), poly sodium N-undecanoy l isoleucyl-valinate (SUILV) with three chiral centers and poly sodium N-un decanoyl leucyl-valinate (SULV) with two chiral centers, have been evaluate d and compared as chiral pseudo-stationary phases in electrokinetic capilla ry chromatography. The performance of these surfactants, in terms of enanti oselectivity was examined using anionic, cationic and neutral analytes. Ana lyses of the data suggest that the enantiomeric resolutions of the analytes with these two PDCSs are dependent upon steric factors rather than number of stereogenic centers. (C) 1999 Published by Elsevier Science B.V. All rig hts reserved.