Fatal case of Trichoderma harzianum infection in a renal transplant recipient

We describe the second known case of human infection by Trichoderma harzian um. A disseminated fungal infection was detected in the postmortem examinat ion of a renal transplant recipient and confirmed in culture. The only othe r reported infection by this fungus caused peritonitis in a diabetic patien t. The in vitro antifungal susceptibilities of the clinical strain and thre e other strains of Trichoderma species to six antifungal drugs are provided . This case illustrates the widening spectrum of opportunistic Trichoderma spp. in immunocompromised patients and emphasizes the problems in diagnosin g invasive fungal diseases.