K. Oyanagi et M. Wada, Neuropathology of parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam: an update, J NEUROL, 246, 1999, pp. 19-27
A comparative study was performed to investigate the differences and simila
rities of the neuropathological findings in the parkinsonism-dementia compl
ex (PDC) and amyotrophic lateral sclerosis (ALS) of Guam, progressive supra
nuclear palsy and classic ALS. Based on the findings, it is proposed that (
a) PDC is a discrete disease entity, (b) NFTs in Chamorro ALS are merely a
background feature widely distributed in this population, (c) Chamorro ALS
is a disease combined with classic ALS and neurofibrillary degeneration, (d
) thus a subtype of "Guam ALS" is not present, and (e) PDC and ALS of Guam
are different diseases.