Evaluation of the H-point standard additions method (HPSAM) and the generalized H-point standard additions method (GHPSAM) for the UV-analysis of two-component mixtures

The H-point standard additions method (HPSAM) and two versions of the gener alized H-point standard additions method (GHPSAM) are evaluated for the UV- analysis of two-component mixtures. Synthetic mixtures of anhydrous caffein e and phenazone as well as of atovaquone and proguanil hydrochloride were u sed. Furthermore, the method was applied to pharmaceutical formulations tha t contain these compounds as active drug substances. This paper shows both the difficulties that are related to the methods and the conditions by whic h acceptable results can be obtained. (C) 1999 Elsevier Science B.V. All ri ghts reserved.