Stent attachment site-related endoleakage after stent graft treatment: An in vitro study of the effects of graft size, stent type, and atherosclerotic wall changes
Gwh. Schurink et al., Stent attachment site-related endoleakage after stent graft treatment: An in vitro study of the effects of graft size, stent type, and atherosclerotic wall changes, J VASC SURG, 30(4), 1999, pp. 658-667
Citations number
20
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Objective: Perigraft endoleakage is a major complication of the endovascula
r treatment of abdominal aortic aneurysms. The factors that cause this form
of endoleakage are not completely identified. The effect of sizing of the
prosthesis in combination with either self-expandable or balloon-expandable
stents is evaluated in this study. Further, the influence of atherosclerot
ic changes on endoleakage is evaluated.
Methods: Eight human abdominal aortas were assessed macroscopically at 11 s
ites for the presence of atherosclerotic changes with intravascular. ultras
ound scanning (IVUS) and with computed tomography (CT). Five aortas were pl
aced in in vitro circulation with physiologic parameters. After the determi
nation of the proximal and distal landing site of the Stent graft, the diam
eter and surface measurements of the cross sections were taken. The stent g
raft diameters were chosen from 4-mm undersizing to 6-mm oversizing, both f
or Gianturco stent grafts (William Cook Europe A/S, Bjaeversltov, Denmark)
and for Palmaz stent grafts (Cordis/Johnson & Johnston Co, Warren, NT). Aft
er placement of the stent graft, the diameter and surface measurements of t
he aortic cross section were determined at the proximal and distal stent at
tachment sites. The presence and size of the folds at the stent attachment
site and the interface with the aortic wall were determined with IVUS and a
ngioscopy. Endoleakage was evaluated with angiography. After angioplasty of
the stent attachment site, IVUS, angioscopy, and angiography were repeated
.
Results: Regarding atherosclerotic changes of the aortic wall, the correlat
ions between clinical impression and CT, clinical impression and IVUS, and
CT and NUS were high (r = 0.77, r = 0.79 and r = 0.79, respectively). For t
he Gianturco stent grafts, no significant relationship existed between the
diameters measured before and after stent graft placement, leading to great
differences in intended and achieved oversizing. The achieved oversizing w
as less in the case of minimal atherosclerotic changes of the aortic wall.
The Gianturco stent graft followed the aortic wall closely during the heart
cycle. The sizes of the folds of the fabric were clearly correlated with t
he achieved oversizing (r = 0.83; P = .04) and the grade of endoleakage (r
= 0.88; P = .022). Angioplasty after stent graft placement had no effect on
the diameter and the grade of endoleakage. Palmaz stent grafts did not fol
low the aortic wall during the heart cycle. A significant correlation exist
ed between oversizing and both space between aortic wall and stent graft (r
= -0.88; P = .02) and grade of endoleakage (r = 0.84; P = .036). Grade of
endoleakage in the Palmaz stent graft group was less than in the Gianturco
stent graft group.
Conclusion: With the use of Gianturco stents, a great difference between in
tended and achieved oversizing is accomplished. The atherosclerotic changes
of the aortic wall possibly affect this finding. The configuration of the
Gianturco stent results in the formation of fold in the case of oversizing,
which is associated with endoleakage. However, the self-expandable charact
er of the stent leads to a close relation to the aortic wall during the hea
rt cycle, and this may possibly accommodate future aortic neck dilation. Th
e Palmaz stent grafts do not follow the aortic wall during the heart cycle,
but they do lead to better interface between the graft and the aortic wall
, which results in less endoleakage.