Minimal incidence of serum antibodies reactive with intact primary isolatevirions in human immunodeficiency virus type 1-infected individuals

Citation
La. Cavacini et al., Minimal incidence of serum antibodies reactive with intact primary isolatevirions in human immunodeficiency virus type 1-infected individuals, J VIROLOGY, 73(11), 1999, pp. 9638-9641
Citations number
26
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF VIROLOGY
ISSN journal
0022538X → ACNP
Volume
73
Issue
11
Year of publication
1999
Pages
9638 - 9641
Database
ISI
SICI code
0022-538X(199911)73:11<9638:MIOSAR>2.0.ZU;2-3
Abstract
Immunoglobulin G reactive with primary isolate virions aas detected in 36% of serum samples from individuals infected with human immunodeficiency viru s type 1. Of these individuals, serum samples from only 7% captured signifi cant quantities of virus. Virion-specific antibody correlated with CD4 coun ts and, of more significance, primary isolate neutralization. Further disse ction of this response should lead to the identification of antibodies and antigenic epitopes for vaccine purposes.