Differences in lung bioavailability between different propellants for fluticasone propionate

Authors
Wilson, AM Sims, EJ Orr, LC Lipworth, BJ
Citation
Am. Wilson et al., Differences in lung bioavailability between different propellants for fluticasone propionate, LANCET, 354(9187), 1999, pp. 1357-1358
Citations number
3
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Journal title
LANCET
ISSN journal
01406736 → ACNP
Volume
354
Issue
9187
Year of publication
1999
Pages
1357 - 1358
Database
ISI
SICI code
0140-6736(19991016)354:9187<1357:DILBBD>2.0.ZU;2-F
Abstract
The lung bioavailability las adrenal suppression) of fluticasone propionate was about two-fold greater with chlorofluorocarbons than hydrofluoroalkane as propellant. Direct switching between formulations on a mu g equivalent may therefore be inadvisable.