Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q)

Authors
Garay, CA Al-Saleem, T Testa, JR Smith, MR
Citation
Ca. Garay et al., Coexisting myelodysplasia and myeloproliferative features in a single clone containing 5q-, Ph and i(17q), LEUK RES, 23(10), 1999, pp. 965-967
Citations number
7
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
23
Issue
10
Year of publication
1999
Pages
965 - 967
Database
ISI
SICI code
0145-2126(199910)23:10<965:CMAMFI>2.0.ZU;2-Z
Abstract
A case with myelodysplasia in which a single clone contained both 5q- and P h chromosomes at diagnosis is presented. The patient subsequently developed leukocytosis and at that time was found to have acquired an additional chr omosomal abnormality, i(17)(q10). This case illustrates the role of three d ifferent genetic changes that impart different clinical characteristics, i. e. myelodysplastic as well as myeloproliferative changes, as part of a mult istep leukemogenic process. (C) 1999 Elsevier Science Ltd. All rights reser ved.