Stobadine inhibits lysosomal enzyme release in vivo and in vitro

This study investigated the ability of stobadine, an effective cardioprotec tive drug with antiarrhythmic, antihypoxic and oxygen free radical scavengi ng properties, to protect cells against cyclophosphamide-induced toxic and cytotoxic damage in vivo and in vitro. Cyclophosphamide-induced toxic damag e in female ICR mice was accompanied by marked increase in the activity of lysosomal enzymes in the spleen and kidney. Administration of stobadine pri or to cyclophosphamide inhibited these biochemical changes. The in vivo pro tective effect of stobadine was comparable with its in vitro effect establi shed in HeLa cells.