V. Bauer et al., Reactive oxygen species induced smooth muscle responses in the intestine, vessels and airways and the effect of antioxidants, LIFE SCI, 65(18-19), 1999, pp. 1909-1917
Numerous experimental data confirm the importance of reactive oxygen specie
s (ROS) in physiological activities of smooth muscles and in the pathogenes
is of various diseases with altered function of smooth muscles. The present
study shows that smooth muscles of the intestine, airways and vessels, as
well as their epithelium, endothelium and innervations, might be important
targets of the ROS action. We demonstrated differences among the actions of
various ROS (endogenous, exogenous, produced enzymatically, non-enzymatica
lly) as well as among their actions in different smooth muscle tissues. Our
results indicate that ROS are involved in changes in muscle tone, membrane
conductance, calcium homeostasis, calcium-dependent processes, as well as
in eicosanoid and nitric oxide metabolism. The effects of antioxidative enz
ymes (superoxide dismutase, catalase), of several drugs of natural origin (
e.g. Kampo Medicines) and synthetic agents (e.g. stobadine, nitrosopine, AC
E inhibitors) suggest that smooth muscle tissues are useful models to study
ROS action and drug intervention in ROS induced injuries.