O. Ondrejickova et al., Effect of stobadine on lipid peroxidation in brain and heart after ischemia and reperfusion of the brain, LIFE SCI, 65(18-19), 1999, pp. 1959-1961
Stobadine (ST), a novel drug with pyridoindol structure, was recently found
to prevent reperfusion injury in rat brain. The aim of the present study w
as to reveal whether ST may prevent peroxidative changes in the heart and b
rain that were triggered by postischemic reperfusion of the brain. In the b
rain, reperfusion significantly increased the contents of malondialdehyde (
MDA) by 43.8 % and conjugated diens (CD) by 24.5% when compared with the en
d of ischemia. In the heart, contents of MDA and CD in reperfusion became e
levated three fold and by 41.7 %, respectively, when comparing to the value
s at the end of ischemia. In the heart, no significant changes in activitie
s of the superoxide dismutase (SOD) and glutathione peroxidase (GPx) induce
d by ischemia or reperfusion were detected. In contrast, reperfusion induce
d a slight decrease in GPx activity in the brain. In accordance with our pr
evious results, an application of ST (2 mg/kg) to the femoral artery shortl
y prior to reperfusion of the ischemic brain, prevented significantly MDA a
nd CD accumulation in brain. Nevertheless, ST was not able to prevent the b
rain-ischemia/reperfusion-induced elevation of MDA and CD contents in the h
eart.