Pharmacokinetic study of stobadine

Authors
Bezek, S Soltes, L Scasnar, V Bauerova, K Kallay, Z Durisova, M Mihalova, D Bohov, P Faberova, V Kukan, M Trnovec, T Koprda, V
Citation
S. Bezek et al., Pharmacokinetic study of stobadine, LIFE SCI, 65(18-19), 1999, pp. 2003-2005
Citations number
15
Categorie Soggetti
Biochemistry & Biophysics
Journal title
LIFE SCIENCES
ISSN journal
00243205 → ACNP
Volume
65
Issue
18-19
Year of publication
1999
Pages
2003 - 2005
Database
ISI
SICI code
0024-3205(19991001)65:18-19<2003:PSOS>2.0.ZU;2-R
Abstract
The aim of this paper is to provide a brief overview of most important resu lts of stobadine kinetic studies in rats, dogs, and human volunteers. In th ese studies, stobadine dihydrochloride and stobadine dipalmitate was used f or intravenous and oral administration, respectively. To evaluate kinetic p roperties of stobadine and its metabolites, TLC, HPLC, GLC, GC-MS, radiomet ric, and fluorometric methods were developed and used.