Receptor-C-k regulates the expression of cyclin-dependent kinase inhibitors (p16; p27)

The present study was addressed to understand the interrelationship between Receptor-C-k induction-activation coupling; isoprenoids (derived from meva lonate pathway) and cyclin-dependent kinase inhibitors. The results reporte d here unambiguously reveal that isoprenoids regulate the expression of gen es coding for CDK inhibited p16 and p27. Further, Receptor-C-k dependent si gnalling, known to control the mevalonate pathway, had a direct effect upon the p27 gene expression. Based upon these studies coupled with our earlier findings we propose that Receptor-C-k has an important role in the regulat ion of cell cycle machinery.