The effects of anxiety on psychiatric morbidity in patients with multiple sclerosis

Our objective was to assess the point prevalence and effects of clinically significant anxiety in patients with Multiple Sclerosis (MS). One hundred a nd fifty two consecutive patients with MS attending an outpatient clinic un derwent neurological examination and were assessed for psychopathology with the Hospital Anxiety and Depression Scale the 28 item General Health Quest ionnaire and a questionnaire probing suicidal thoughts or intent Clinically significant anxiety, either with or without depression, was endorsed by 25 % of patients, three times the rate for depression. Females were significan tly more anxious than males. Anxiety co-morbid with depression, rather than anxiety or depression alone, was associated with increased thoughts of sel f harm, more somatic complaints and greater social dysfunction. Patients wi th increased psychopathology were not more likely to be taking psychotropic medication. The results provide preliminary evidence that anxiety which ma y be often overlooked clinically, is a frequent accompaniment to depression , thereby adding to the morbidity associated with MS. The implications of t he findings to MS patients' quality of life ore emphasised.