S. Visonneau et al., Adoptive therapy of canine metastatic mammary carcinoma with the human MHCnon-restricted cytotoxic T-cell line TALL-104, ONCOL REP, 6(6), 1999, pp. 1181-1188
Adoptive transfer of human TALL-104 killer cells into a dog with metastatic
mammary adenocarcinoma resulted in 50% reduction of the largest lung metas
tasis and stabilization of the other lesions for 10 weeks, accompanied by t
he development of tumor-specific immune responses. Upon halting cell therap
y, the dog developed new lung lesions within 10 weeks and died of slowly pr
ogressive disease. TALL-104 cell therapy of mice bearing the dog's tumor xe
nograft induced 65% reduction of local tumor growth and repression of lung
metastases in 100% of the animals. The overall findings indicate the therap
eutic potential of TALL-104 cells for canine mammary tumors.