CLINICAL AND FLOW CYTOMETRIC PROGNOSTIC FACTORS IN SURGICALLY TREATEDSQUAMOUS-CELL LUNG-CANCER

Authors
KOLODZIEJSKI L NIEZABITOWSKI A GASINSKA A
Citation
L. Kolodziejski et al., CLINICAL AND FLOW CYTOMETRIC PROGNOSTIC FACTORS IN SURGICALLY TREATEDSQUAMOUS-CELL LUNG-CANCER, Lung cancer, 16(2-3), 1997, pp. 173-182
Citations number
35
Categorie Soggetti
Oncology,"Respiratory System
Journal title
Lung cancer → ACNP
ISSN journal
01695002
Volume
16
Issue
2-3
Year of publication
1997
Pages
173 - 182
Database
ISI
SICI code
0169-5002(1997)16:2-3<173:CAFCPF>2.0.ZU;2-E
Abstract
A five-year follow-up study of prognostic factors in 207 patients with squamous cell lung cancer (SqLC) radically treated with surgery was i nvestigated. Cellular prognostic indicators for survival times, such a s percentage of cells in the S-phase (S-phase fraction, SPF), prolifer ative index (PI, number of cells in S + G(2)/M phases) and DNA ploidy, in addition to well known clinical factors were studied. Patients wit h aneuploid tumours had significantly shorter survival period (P < 0.0 5) than patients with diploid tumours. However, proliferative rate of the tumours had no influence on patients' survival. Cox multivariate a nalysis showed that metastases to the neighbouring lymph nodes, tumour diameter >5 cm and DNA aneuploidy of the tumour cells were the negati ve factors which affected patients survival. DNA ploidy did not depend on the clinical stage of the tumours. (C) 1997 Elsevier Science Irela nd Ltd.