L. Kolodziejski et al., CLINICAL AND FLOW CYTOMETRIC PROGNOSTIC FACTORS IN SURGICALLY TREATEDSQUAMOUS-CELL LUNG-CANCER, Lung cancer, 16(2-3), 1997, pp. 173-182
A five-year follow-up study of prognostic factors in 207 patients with
squamous cell lung cancer (SqLC) radically treated with surgery was i
nvestigated. Cellular prognostic indicators for survival times, such a
s percentage of cells in the S-phase (S-phase fraction, SPF), prolifer
ative index (PI, number of cells in S + G(2)/M phases) and DNA ploidy,
in addition to well known clinical factors were studied. Patients wit
h aneuploid tumours had significantly shorter survival period (P < 0.0
5) than patients with diploid tumours. However, proliferative rate of
the tumours had no influence on patients' survival. Cox multivariate a
nalysis showed that metastases to the neighbouring lymph nodes, tumour
diameter >5 cm and DNA aneuploidy of the tumour cells were the negati
ve factors which affected patients survival. DNA ploidy did not depend
on the clinical stage of the tumours. (C) 1997 Elsevier Science Irela
nd Ltd.