The effect of midazolam sedation on indicators for myocardial ischemia

Objective. The purpose of this investigation was to examine hemodynamic and electrocardiographic responses to local anesthesia. Study design, Seventy-five patients with heart disease were treated in 2 gr oups with lignocaine 2%, adrenaline 1:50,000, and vasopressin 0.25 IU, eith er alone or with midazolam. Heart rate, blood pressure, and electrocardiogr am values were recorded, and the rate-pressure product and pressure-rate qu otient were calculated as indicators for myocardial ischemia. Results, Sedation and anesthesia induced significant changes to the means f or heart rate and systolic and mean blood pressure. For the anesthetic grou p, the maximum value for the rate-pressure product was 12,168 (95% CI = 136 8), the minimum value for the pressure-rate quotient was 1.39 (95% CI = 0.0 4), and one patient exhibited minor changes to the S-T segment. For the sed ated group, the rate-pressure product maximum was 9,882 (95% CI = 1,226) an d the pressure-rate quotient fell to 1.13 (95% CI = 0.06), but no patient e xperienced ischemia. Conclusion. Values for these indicators suggested that treatment did not ge nerate significant ischemic risk.