We apply causality considerations to active-sterile neutrino transformation
-based schemes for lepton number generation in the early Universe. These co
nsiderations necessarily lead to the creation of spatial domains of lepton
number with opposite signs. Lepton number gradients at domain boundaries ca
n open a new channel for Mikheyev-Smirnov-Wolfenstein resonant production o
f sterile neutrinos (nu(s)). This enhanced nu(s) production allows consider
able tightening of big bang nucleosynthesis constraints on active-sterile n
eutrino mixing.