P. Ngouemo et al., EFFECTS OF ETHANOL EXTRACT OF ANNONA-MURICATA ON PENTYLENETETRAZOL-INDUCED CONVULSIVE SEIZURES IN MICE, PTR. Phytotherapy research, 11(3), 1997, pp. 243-245
The effects of an ethanol extract of the mature leaves of Annona muric
ata (Annonaceae), were investigated on pentylenetetrazol (PTZ)-induced
clonic-tonic seizures in mice. The latency of clonic PTZ seizures and
the incidence of clonic and tonic episodes of PTZ seizures were analy
sed. The results demonstrated that the plant extract significantly red
uced the incidence of tonic PTZ seizures and mortality and lengthened
the onset to clonic PTZ seizures. This study indicates that extract of
the leaves of A. muricata contains active substance(s) that preferent
ially suppressed the tonic phase of PTZ-induced clonic-tonic seizures.
(C) 1997 by John Wiley & Sons, Ltd.