REGRESSION OF CARDIAC-HYPERTROPHY IN HYPERTENSIVE PATIENTS - COMPARISON OF ABANA WITH PROPRANOLOL

The effect of Abana and propranolol on left ventricular hypertrophy in hypertensive individuals was studied by echocardiography. The study s howed an improvement in cardiac function as indicated by an increase i n ejection fraction and fractional shortening in both the Abana- and p ropranolol-treated groups. A decrease in cardiac mass with propranolol was seen at 12 weeks and was maintained up to 36 weeks. With Abana th e reduction in mass was seen from 18 weeks onwards and lasted up to 42 weeks. In five patients on Abana and two on propranolol, the trial wa s continued for a further period of 84 weeks, but the effects seen at 84 weeks were not significantly different from these at 60 weeks. (C) 1997 by John Wiley & Sons, Ltd.