Temperature gradient interaction chromatography of low molecular weight polystyrene

Separation of low molecular weight polystyrene (PS) by temperature gradient interaction chromatography (TGIC) is reported, As in the separation of hig h molecular weight PS, temperature is an efficient variable to control the retention of low molecular weight PS in the reversed phase HPLC separation. However, a right choice of the eluent, typically a marginal solvent for th e polymeric solute of interest, is crucial for the temperature to play an e ffective role in the retention control. For an example, PS oligomers were w ell separated by TGIC under the isocratic elution condition of C18 bonded s ilica and methanol as the stationary and the mobile phase, respectively. (C ) 1999 Elsevier Science Ltd, All rights reserved.