When to try COX-2-specific inhibitors - Safer than standard NSAIDs in somesituations

Cyclooxygenase-2 (COX-2) inhibitors are the latest addition to the growing armamentarium of antiinflammatory drugs. Their ability to selectively block formation of proinflammatory prostaglandins while sparing those that guard the gastrointestinal tract makes them an attractive choice for long-term u se, such as in rheumatic disease. More COX-2 inhibitors will undoubtedly be come available, so primary care physicians should be aware of their advanta ges and limitations. In this article, the authors describe the pharmacokine tics and use of these agents.