F. Samdal et al., ALKALIZATION OF LIGNOCAINE-ADRENALINE REDUCES THE AMOUNT OF PAIN DURING SUBCUTANEOUS INJECTION OF LOCAL-ANESTHETIC, Scandinavian journal of plastic and reconstructive surgery and hand surgery, 28(1), 1994, pp. 33-37
A double blind, randomised controlled trial was performed to compare t
he amount of pain experienced after subcutaneous infiltration of ligno
caine with adrenaline, and the same anaesthetic buffered to pH 7.1-7.3
, in patients undergoing liposuction (n = 8), blepharoplasty (n = 7),
mammaplasty (n = 6), and in volunteers (n = 10). A linear analogue pai
n scale was used to access pain. In all four groups the buffered solut
ion caused significantly less pain (p < 0.001 except for mammaplasty-p
= 0.02).